Faculty
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Division of Clinical Care and Research
Nicholas Stamatos, M.D., Ph.D.
Assistant Professor,
University of Maryland School of Medicine, Baltimore
nstamatos@ihv.umaryland.edu
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Profile |
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Dr. Stamatos is an Assistant Professor in the Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine. Since coming to the Institute of Human Virology in 1998, Dr. Stamatos has contributed significantly towards the Institute's clinical, research and educational objectives.
Dr. Stamatos is board certified in Internal Medicine and Infectious Diseases. He is very active in the University of Maryland Medical System's in-patient and out-patient Medicine/Infectious Diseases services. Additionally, he presents lectures for the Medical Microbiology course for 2nd year medical students in the University of Maryland Medical School and instructs ID fellows, medical residents, interns and medical students.
Dr. Stamatos has extensive experience studying animal viruses. He began his research career at Sloan Kettering Cancer Center studying the mechanism of assembly of the 10 strands of reovirus RNA into mature virus particles. As a predoctoral student at the University of Rochester, he studied the mechanism whereby polyomavirus proteins moved from their site of synthesis in the cytoplasm into the nucleus where viral assembly occurred.
He was a postdoctoral fellow in Laboratory of Viral Diseases at the National Institutes of Health, where he studied transcription of vaccinia virus RNAs. Prior to coming to the University of Maryland, he was a research scientist at the Walter Reed Army Institute of Research, where he characterized epitopes on the HIV envelope gp120/41 that generate neutralizing antibodies. He is currently studying endogenous sialidases of cells of the immune system and is characterizing their role in the infectivity of peripheral blood mononuclear cells by HIV.
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Education |
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B.A. - Government/Economics, Boston University, Boston, MA, 1977. |
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M.S. - Microbiology/Immunology, University of Rochester, Rochester, NY, 1985. |
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Ph.D. - Microbiology/Immunology, University of Rochester, Rochester, NY, 1987. |
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M.D. - Medicine, George Washington University, Washington, D.C., 1991. |
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Selected Publications |
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Stamatos, N. M., Gomatos, P. J., Cox, J., Fowler, A., Dow, N., Wohlhieter, J. A. and A. S. Cross. 1997. Desialylation of peripheral blood mononuclear cells promotes growth of HIV-1. Virology 228:123-131 |
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Stamatos, N. M., Mascola, J., Kalyanaraman, V., Louder, M., Birx, D. and T. VanCott. 1998. Neutralizing antibodies from the sera of human immunodeficiency virus type 1-infected individuals bind to monomeric gp120 and oligomeric gp140. J. Virol. 72:9656-9667 |
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Cross, A.S., Sakarya, S., Rifat, S., Held, T.K., Drysdale, B.E., Grange, P.A., Cassels, F.J., Wang, L.X., Stamatos, N.M., Farese, A., Casey, D., Powell, J., Bhattacharjee, A.K., Kleinberg, M. and S. E. Goldblum. 2003. Recruitment of murine neutrophils in vivo through endogenous sialidase activity. J. Biol. Chem. 278:4112-4120. |
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Stamatos, N.M., Curreli, S., Zella, D. and A. S. Cross. Desialylation of glycoconjugates on the surface of monocytes activates the extracellular signal-related kinases ERK 1/2 and results in enhanced production of specific cytokines. In press. J. Leuk. Biol. (Feb, 2004) |
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Stamatos, N.M., Liang, F., Wang, L. X., Cross, A. S. and A. Pshezhetsky. Endogenous sialidase activity of human monocytes is up-regulated during cellular differentiation into macrophages. Submitted, J. Biol. Chem., 2003. |
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Stamatos, N.M. and L.X. Wang. Inhibition of the endogenous sialidase of macrophages blocks their productive infection with R5 HIV-1BaL. In preparation.
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Research Interests |
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Click here to view Dr. Stamato's Research Interests |
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