Faculty
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Profile |
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Pathogenesis of arenavirus hemorrhagic fever and arenavirus vaccines; Mechanisms of virus-mediated cell death in AIDS; Use of animal models, and genomic/proteomic approaches to analyze virus/host interactions.
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Education |
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• B.A. - Zoology, University of California, Los Angeles, 1972.
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• Ph.D. - Molecular Biology, University of California, Berkeley, 1977.
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• Postdoctoral Fellow - Molecular Biology, University of California, San Francisco, 1977-81. |
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Awards and Honors |
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1977-80 - Damon Runyan-Walter Winchell Postdoctoral Fellow, Department of Biochemistry and Biophysics, University of California-San Francisco. |
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Fellow of the British/American Heart Association, Medical Research Council, Cambridge, UK |
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NIH International Cooperative Projects Study Section (empaneled member) |
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Publications |
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1. |
Djavani M, Yin CC, Lukashevich IS, Rodas JD, Rai SK, and Salvato MS. 2001. Mucosal immunization with Salmonella typhimurium expressing Lassa virus nucleocapsid protein cross-protects mice from lethal challenge with lymphocytic choriomeningitis virus. J. Hum Virol. 4: 103-108. |
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Djavani M, Rodas JD, Lukashevich IS, Horejsh D, Pandolfi PP, Borden KLB, Salvato MS. 2001. Role of the promyelocytic leukemia protein (PML) in the interferon-sensitivity of lymphocytic choriomeningitis virus. J. Virol. 75: 6204-6208. |
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Bonilla WV, Pinschewer DD, Klenerman P, Gaboli M, Pandolfi PP, Zinkernagel RM, Salvato MS, Hengartner H. 2002. A critical role for promyelocytic leukemia protein in control and outcome of RNA virus infections in vivo. J Virol. 76: 3810-3818. |
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Lukashevich IS, Rodas JD, Djavani M, Usborne A, Emerson C, Mitchen J, Jahrling PB, Salvato MS. 2002. Lymphocytic choriomeningitis virus infection of rhesus macaque causes hemorrhagic fever after intravenous but not after intragastric inoculation. J Med Virol. 67: 171-186. |
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Lukashevich IS, Tikhonov I, Rodas JD, Zapata JC, Yang Y, Djavani M, Salvato MS. 2002. Arenavirus-mediated liver pathology: Acute LCMV infection of rhesus macaques is characterized by high IL-6 expression and hepatocyte proliferation. J Virol. Submitted. |
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Yin C, Yang Y, Yagita H, Salvato MS. 2002. Expression of SIV or HIV env sensitizes cells to FasL-mediated apoptosis. J. Virol. Submitted. |
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Yang Y, Tikhonov I, Ruckwardt T, Djavani M, Zapata JC, Pauza CD, Salvato MS. 2002 HIV Tat induces secretion of TRAIL by monocytes that is capable of killing uninfected bystander cells. J Virol.in press |
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Rodas, J D, Lukashevich IS, Zapata JC, Cairo C, Tikhonov I,Djavani M, Pauza CD, Salvato MS 2004. Mucosal arenavirus infection of primates can protect them from lethal hemorrhagic fever. J Med Virol 72: 424-35. |
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Djavani, M, I Topisirovic, J C Zapata, M Sadowska, Y Yang, J Rodas, IS Lukashevich, CW Bogue, C. D. Pauza, K L Borden and MS Salvato (2005). The proline-rich homeodomain (PRH/HEX) protein is down-regulated in liver during infection with lymphocytic choriomeningitis virus. J Virol 79:2461-73. |
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Lukashevich IS, PattersonJ, Carrion R, Moshkoff D, Ticer A, Zapata J, Brasky K, Geiger R, Hubbard GB, Bryant J, Salvato MS. 2005 A Live attenuated vaccine for Lassa fever made by reassortment of Lassa and Mopeia Viruses. J Virol 79:13934-13942. |
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Bredenbeek, P J, Molenkamp R, Spaan WJM, Deubel V, Marianneau P, Salvato MS, Moshkoff D, Zapata J, Tikhonov I, Patterson J, Carrion R, Ticer A, Brasky K, Lukashevich IS. A recombinant Yellow Fever 17D vaccine expressiong Lassa virus glycoproteins. Virology 345(2):299-304 |
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Garcia C, Djavani M, Topisirovic I,, Borden KLB, Salvato MS, Damonte EB, 2006. The arenavirus Z protein as an antiviral target: virus inactivation and protein oligomerization by zinc-finger reactive compounds. Virology in press. |
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Research Interests |
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Click here to view Dr. Salvato's Research Interests |
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