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Faculty


Division of Basic Science

Marvin Reitz, Ph.D.
Professor and Associate Director, Basic Science Division, IHV, UMBI
Laboratory of Viral Carcinogenesis

mreitz@ihv.umaryland.edu

   Photo: Marvin Reitz, Ph.D.

  Profile
 

Dr. Reitz obtained his Ph.D. in 1970 from the Department of Biochemistry at Purdue University. His graduate work in the field of enzymology was supervised by Professor Victor Rodwell, a recognized scholar in studies of enzymes of amino acid catabolism.

Dr. Reitz trained as a postdoctoral fellow at the Boston Biomedical Research Institute in the laboratory of Dr. Rao Sanadi in the field of tRNA and tRNA aminoacyl synthetases. He was recruited as a staff scientist to Bionetics Research Laboratory in 1971 as part of the laboratory group of Dr. Robert Gallo, and joined him at NIH in 1976. He received tenure in 1984, became Head of the Molecular Biology of Hematopoietic Cells Section in 1992 and Acting Chief of the Laboratory of Tumor Cell Biology in 1995 when Dr. Gallo left to found the IHV.

Dr. Reitz was recruited to the IHV as a tenure track Associate Professor and Associate Director of the Basic Science Division in February 1996 and became Professor with full tenure in 1998. His expertise is in the fields of molecular biology and virology, especially retroviruses and herpesviruses. He is focused on host cell-virus interactions and their effects on immunopathology and carcinogenesis at the level of regulation of signaling and gene expression.
  Education
 

•

 B.A.- Chemistry, Biology minor, Western Maryland College, Westminster, MD, 1965.
• Ph.D. - Biochemistry, Purdue University, West Lafayette, IN, 1970.
  Selected Publications
  1. Guo,H.-G., Sadowska,M., Reid,W., Tschachler,E., Hayward,G.S., and Reitz,M.S. (2003). Kaposi's sarcoma-like tumors in a human herpesvirus 8 ORF74 transgenic mouse. J Virol 77, 2631-2639.
  2. Pal,R., Taylor,B.A., Foulke,J.S., Woodward,R., Merges,M., Praschunis,R., Gibson,A., and Reitz,M. (2003). Characterization of a simian-human immunodeficiency virus encoding the envelope gene from the CCR5-tropic HIV-1 Ba-l. JAIDS (in press).
  3. Pati,S., Foulke,J.S., Jr., Barabitskaya,O., Kim,J., Nair,B.C., Hone,D., Smart,J., Feldman,R.A., and Reitz,M. (2003). Human herpesvirus 8-encoded vGPCR activates nuclear factor of activated T cells and collaborates with human immunodeficiency virus type 1 Tat. J Virol 77, 5759-5773.
  4. Agwale,S.M., Shata,M.T., Reitz,M.S., Jr., Kalyanaraman,V.S., Gallo,R.C., Popovic,M., and Hone,D.M. (2002). A Tat subunit vaccine confers protective immunity against the immune-modulating activity of the human immunodeficiency virus type-1 Tat protein in mice. Proc. Natl. Acad. Sci. U. S. A. 99, 10037-10041.
  5. Pati,S., Pelser,C.B., Dufraine,J., Bryant,J.L., Reitz,M.S., Jr., and Weichold,F.F. (2002). Antitumorigenic effects of HIV protease inhibitor ritonavir: inhibition of Kaposi sarcoma. Blood 99, 3771-3779
  6 Agwale,S.M., Robbins,K.E., Odama,L., Saekhou,A., Zeh,C., Edubio,A., Njoku,O.M., Sani-Gwarzo,N., Gboun,M.F., Gao,F., Reitz,M., Hone,D., Folks,T.M., Pieniazek,D., Wambebe,C., and Kalish,M.L. (2001). Development of an env gp41-based heteroduplex mobility assay for rapid human immunodeficiency virus type 1 subtyping. J Clin Microbiol 39, 2110-2114.
  7 Bodor,J., Feigenbaum,L., Bodorova,J., Bare,C., Reitz,M.S., Jr., and Gress,R.E. (2001). Suppression of T-cell responsiveness by inducible cAMP early repressor (ICER). J. Leukoc. Biol. 69, 1053-1059.
  8 Miller,E.D., Duus,K.M., Townsend,M., Yi,Y., Collman,R., Reitz,M., and Su,L. (2001). Human immunodeficiency virus type 1 IIIB selected for replication in vivo exhibits increased envelope glycoproteins in virions without alteration in coreceptor usage: separation of in vivo replication from macrophage tropism. J. Virol. 75, 8498-8506.
  9 Pati,S., Cavrois,M., Guo,H.G., Foulke,J.S., Jr., Kim,J., Feldman,R.A., and Reitz,M. (2001). Activation of NF-kappaB by the human herpesvirus 8 chemokine receptor ORF74: evidence for a paracrine model of Kaposi's sarcoma pathogenesis. J. Virol. 75, 8660-8673.
  10 Reid,W., Sadowska,M., Denaro,F., Rao,S., Foulke,J., Jr., Hayes,N., Jones,O., Doodnauth,D., Davis,H., Sill,A., O'Driscoll,P., Huso,D., Fouts,T., Lewis,G., Hill,M., Kamin-Lewis,R., Wei,C., Ray,P., Gallo,R.C., Reitz,M., and Bryant,J. (2001). An HIV-1 transgenic rat that develops HIV-related pathology and immunologic dysfunction. Proc. Natl. Acad. Sci. U. S. A. 98, 9271-9276.
  11 Poole,L.J., Zong,J.C., Ciufo,D.M., Alcendor,D.J., Cannon,J.S., Ambinder,R., Orenstein,J.M., Reitz,M.S., and Hayward,G.S. (1999). Comparison of Genetic Variability at Multiple Loci across the Genomes of the Major Subtypes of Kaposi's Sarcoma-Associated Herpesvirus Reveals Evidence for Recombination and for Two Distinct Types of Open Reading Frame K15 Alleles at the Right- Hand End. J. Virol. 73, 6646-6660.
  12 Reitz,M.S., Jr., Nerurkar,L.S., and Gallo,R.C. (1999). Perspective on Kaposi's sarcoma: facts, concepts, and conjectures. J. Natl. Cancer Inst. 91, 1453-1458.
  13 Tschachler,E., Reitz,M.S., Jr., and Franchini,G. (1999). Human retroviral disease: human T-lymphotropic viruses. In Fitzpatrick's Dermatology in General Medicine, I.M.Freedberg, A.Z.Eisen, K.Wolff, K.F.Austen, L.A.Goldsmith, S.I.Katz, and T.B.Fitzpatrick, eds. (New York: McGraw-Hill), pp. 2497-2505.
  14 Weichold,F.F., Bryant,J.L., Pati,S., Barabitskaya,O., Gallo,R.C., and Reitz,M.S., Jr. (1999). HIV-1 protease inhibitor ritonavir modulates susceptibility to apoptosis of uninfected T cells [In Process Citation]. J. Hum. Virol. 2, 261-269.
  15 Zella,D., Barabitskaja,O., Casareto,L., Romerio,F., Secchiero,P., Reitz,M.S., Jr., Gallo,R.C., and Weichold,F.F. (1999). Recombinant IFN-alpha (2b) increases the expression of apoptosis receptor CD95 and chemokine receptors CCR1 and CCR3 in monocytoid cells. J. Immunol. 163, 3169-3175.
  16 Cara,A., Rybak,S.M., Newton,D.L., Crowley,R., Rottschafer,S.E., Reitz,M.S., Jr., and Gusella,G.L. (1998). Inhibition of HIV-1 replication by combined expression of gag dominant negative mutant and a human ribonuclease in a tightly controlled HIV-1 inducible vector. Gene Ther. 5, 65-75.
  17 Flamand,L., Romerio,F., Reitz,M.S., and Gallo,R.C. (1998). CD4 promoter transactivation by human herpesvirus 6. J. Virol. 72 , 8797-8805.
  18 Nicholas,J., Zong,J.C., Alcendor,D.J., Ciufo,D.M., Poole,L.J., Sarisky,R.T., Chiou,C.J., Zhang,X., Wan,X., Guo,H.G., Reitz,M.S., and Hayward,G.S. (1998). Novel organizational features, captured cellular genes, and strain variability within the genome of KSHV/HHV8. J. Natl. Cancer Inst. Monogr. 79-88.
  19 Secchiero,P., Zella,D., Barabitskaja,O., Reitz,M.S., Capitani,S., Gallo,R.C., and Zauli,G. (1998). Progressive and persistent downregulation of surface CXCR4 in CD4(+) T cells infected with human herpesvirus 7. Blood 92, 4521-4528.
  20 Zella,D., Riva,A., Weichold,F.F., Reitz,M.S., Jr., and Gerna,G. (1998). A novel sensitive assay to define immune status using short-term peripheral blood derived cell culture and dual-color flow cytometry. Immunol. Lett. 62, 45-49.
  21 Zella,D., Barabitskaja,O., Burns,J.M., Romerio,F., Dunn,D.E., Revello,M.G., Gerna,G., Reitz,M.S., Jr., Gallo,R.C., and Weichold,F.F. (1998). Interferon-gamma increases expression of chemokine receptors CCR1, CCR3, and CCR5, but not CXCR4 in monocytoid U937 cells. Blood 91, 4444-4450.
  22 Cheng,E.H., Nicholas,J., Bellows,D.S., Hayward,G.S., Guo,H.-G., Reitz,M.S., and Hardwick,J.M. (1997). A Bcl-2 homolog encoded by Kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with Bax or Bak. Proc. Natl. Acad. Sci. U. S. A. 94, 690-694.
  23 Davis,M.A., Sturzl,M., Blasig,C., Schreier,A., Guo,H.G., Reitz,M.S., Opalenik,S.R., and Browning,P.J. (1997). Expression of human herpesvirus 8-encoded cyclin D in Kaposi's sarcoma spindle cells. J. Natl. Cancer Inst. 89, 1868-1874.
  24 Fiorentini,S., Matczak,E., Gallo,R.C., Reitz,M.S., Keydar,I., and Watkins,B.A. (1997). Humanization of an antibody recognizing a breast cancer specific epitope by CDR-grafting. Immunotechnology. 3, 45-59.
  25 Guo,H.-G., Browning,P., Nicholas,J., Hayward,G.S., Tschachler,E., Jiang,Y.W., Sadowska,M., Raffeld,M., Colombini,S., Gallo,R.C., and Reitz,M.S. (1997). Characterization of a chemokine receptor-related gene in human herpesvirus 8 and its expression in Kaposi's sarcoma. Virology 228, 371-378.
  26 Nicholas,J., Ruvolo,V., Zong,J., Ciufo,D., Guo,H.-G., Reitz,M.S., and Hayward,G.S. (1997). A single 13 kilobase divergent locus in the Kaposi sarcoma associated herpesvirus (HHV-8) genome contains nine open reading frames that are homologous to or related to cellular proteins A single 13-kilobase divergent locus in the Kaposi sarcoma- associated herpesvirus (human herpesvirus 8) genome contains nine open reading frames that are homologous to or related to cellular proteins. J. Virol. 71, 1963-1974.
  27 Nicholas,J., Ruvolo,V., Burns,W.H., Sandford,G., Wan,X., Ciufo,D., Hendrickson,S.B., Guo,H.-G., Hayward,G.S., and Reitz,M.S. (1997). Kaposi's sarcoma-associated human herpesvirus-8 encodes homologues of macrophage inflammatory protein-1 and interleukin-6. Nat. Med. 3, 287-292.
  28 Secchiero, P., Berneman, Z. N., Sun, D., Nicholas, J., and Reitz, M. S. Identification of envelope glycoproteins H and B homologues of human herpesvirus 7. Intervirology (in press). 1997.
  29 Secchiero,P., Sun,D., De Vico,A.L., Crowley,R.W., Reitz,M.S., Zauli,G., Lusso,P., and Gallo,R.C. (1997). Role of the extracellular domain of human herpesvirus 7 glycoprotein B in virus binding to cell surface heparan sulfate proteoglycans Role of the extracellular domain of human herpesvirus 7 glycoprotein B in virus binding to cell surface heparan sulfate proteoglycans. J. Virol. 71, 4571-4580.
  30 Watkins,B.A., Crowley,R., Davis,A.E., Louie,A.T., and Reitz,M.S., Jr. (1997). Syncytium formation induced by human immunodeficiency virus type 1 isolates correlates with affinity for CD4. J. Gen. Virol. 78, 2513-2522.
  31 Zong,J.C., Metroka,C., Reitz,M.S., Nicholas,J., and Hayward,G.S. (1997). Strain variability among Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genomes: evidence that a large cohort of United States AIDS patients may have been infected by a single common isolate. J. Virol. 71, 2505-2511.
  32 Cara,A., Cereseto,A., Lori,F., and Reitz,M.S., Jr. (1996). HIV-1 protein expression from synthetic circles of DNA mimicking the extrachromosomal forms of viral DNA. J. Biol. Chem. 271, 5393-5397.
  33 Cara,A., Cereseto,A., Fiorentini,S., Gusella,L., and Reitz,M.S. (1996). Low levels of reverse transcriptase associated with one integrase defective mutant of HIV-1. Fundamental and Clin. Immunol. 4, 61-66
  34 Watkins,B.A., Buge,S., Aldrich,K., Davis,A.E., Robinson,J., Reitz,M.S., and Robert-Guroff,M. (1996). Resistance of human immunodeficiency virus type 1 to neutralization by natural antisera occurs through single amino acid substitutions that cause changes in antibody binding at multiple sites. J. Virol. 70, 8431-8437.
  35 Watkins,B.A. and Reitz,M.S., Jr. (1996). Using PCR for rapid site-specific mutagenesis in large plasmids. Methods Mol. Biol. 57, 217-227.
  36. Watkins,B.A., Davis,A.E., Fiorentini,S., di Marzo Veronese,F., and Reitz,M.S. (1996). Evidence for distinct contributions of heavy and light chains to restriction of antibody recognition of the HIV-1 principal neutralization determinant. J. Immunol. 156, 1676-1683.
  37.

Watkins,B.A., Crowley,R.W., Davis,A.E., Louie,A.T., and Reitz,M.S. (1996). Expression of CD26 does not correlate with the replication of macrophage-tropic strains of HIV-1 in T-cell lines. Virology 224, 276-280.
  Research Interests
  Click here to view Dr. Reitz's Research Interests
University of Maryland Biotechnology InstituteUniversity of Maryland Medical System The Institute of Human Virology
725 West Lombard Street
Baltimore, Maryland 21201 USA
Office: 410-706-8614 Fax: 410-706-1952