Faculty
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Profile |
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Our laboratory is interested in the development and characterization of HIV-1 and Human Herpesvirus 8 (HHV-8) rodent models. We engineer animal models by transgenic and gene-knock out techniques.
Over the last several years, our focus has been on analyzing the molecular and immunological bases for cytokine (interferon-gamma) dysregulation seen in the transgenic HIV-1 rat and Kaposi's Sarcoma-like tumors in transgenic HHV8 G protein-coupled receptor mouse models respectively.
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Education |
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B.S. - Animal Science, University of Maryland, College Park.
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D.V.M. - Veterinary Medicine, Tuskegee University, Tuskegee, Alabama. |
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Postdoctoral Scholar - Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor. |
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Awards and Honors |
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HIV Transgenic Animals and Uses Thereof. U.S. Patent Number: 6,156,952. |
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Publications |
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1. |
Baron, L.S., Kopecko, D.J., McCowen, S.M., Snellings, N.G., Johnson, E.M., Reid, W.C., Life, C.A. Genetic and Molecular Studies of the Regulation of Atypical Citrate Utilization and Variable Vi Antigen Expression in Enteric Bacteria. Basic Life Sciences. (1982); 19:175-94 |
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Chrisp, C., Reid, W.C., Rush, H., Suckow, M., Bush, A., Thomann, M. Characterization of Cryptosporidiosis in Guinea Pigs: An Animal Model. Infection and Immunity, March 1990. |
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Eqwtiaqti, C.E., Sztein J., Reid, W.C., Cheipelinsky A.B. Ectopic Gamma Interferon in the Eyes of Transgenic Mice Induces Ocular Pathology and MHC Class 11 Gene Expression. Investigative Ophthalmology and Visual Science.Vol.35(2);1994. |
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Reid, W.C., Carmichael K.P., Srinivas S., Bryant J.L. Pathology Associated With the Use of Tribromoethanol (Avertin) in the Sprague-Dawley Rat. Laboratory Animal Science, Vol. 49(6);1999. |
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Reid, W.C., Sadowska, M., Lewis, G., Gallo R., Reitz, M. and Bryant, J et. al. An HIV-1 transgenic rat that develops HIV-related pathology and immunologic dsfunction. PNAS, Vol 98(16);2001. |
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H.-G. Guo, M. Sadowska, Reid, W.C., E. Tschachler, G. Hayward, and M. Reitz. Kaposi's Sarcoma-Like Tumors in a Human Herpesvirus 8 ORF74 Transgenic Mouse, J Virol, Vol. 77(4); 2003. |
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Clinical Trials |
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Click here to visit the Clinical Trials section of our site. |
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