Faculty


Division of Basic Science and Vaccine Research

M. Mark Djavani, Ph.D.
Senior Scientist, UMBI
mdjavani@ihv.umaryland.edu

Profile Publications
Education Research Interests
  M. Mark Djavani

Profile

Diagnosis and pathogenesis of arenavirus hemorrhagic fever and arenavirus vaccines; Genomic and proteomic approaches to analyze virus/host interactions.

Education

Postdoctoral Fellow - Viral Pathogenesis, University of Wisconsin, Madison, WI, 1993-99.
Ph.D. - Biochemistry, Dokuz Eylul University, Izmir, Turkey, 1992.

B.A. - Pharmacy, Ege University, Izmir, Turkey, 1985.
Selected Publications
1. Djavani M, Topisirovic I, Zapata JC, Sadowska M, Yang Y, Lukashevich IS, Borden KLB, Pauza CD, Salvato MS. (2005). The proline-rich homeodomain (PRH/HEX) protein is down-regulated in liver during Infection with lymphocytic choriomeningitis virus. J Virol. 9(4):2461-2473
2. Garcia CC, Djavani M, Topisirovic I, Borden KLB, Salvato MS, Damonte EB. (2006). The arenavirus Z protein as an antiviral target: virus inactivation and protein oligomerization by zinc-finger reactive compounds. In Press.
3. Lukashevich IS / Djavani M, Rodas J, Usborne A, Emerson C, Mitchen J, Jahrling PB, Salvato MS. (2002). Hemorrhagic fever occurs after intravenous, but not after intragastric inoculation of rhesus macaques with Lymphocytic choriomeningitis virus. J. Med. Virol. 67:171-186 .
4. Djavani M, Rodas J, Lukashevich IS, Horejsh D, Pandolfi PP, Borden KLB, Salvato MS. (2001). Role of the promyelocytic leukemia protein (PML) in the interferon-sensitivity of LCMV. J. Virol. 75 (13): 6204-6208
5. Djavani M, Yin C, Lukashevich IS, Rodas J, Rai, SK, Salvato MS. (2001). Mucosal immunization with S. typhimurium expressing Lassa virus NP cross-protects mice from lethal challenge with LCMV. J. Hum.Virol. 4 (2): 103-108.
6. Djavani M, Yin C, Xia L, Lukashevich IS, Pauza CD, Salvato M. (2000). Murine immune responses to mucosally delivered Salmonella expressing Lassa virus nucleoprotein. Vaccine 18: 1543-1554.
7. Wallace M., Pyzalski R., Horejsh D., Brown C., Djavani M., Lu Y., Hanson J.M., Mitchen J.L., Perlman S.B. and Pauza C.D. (2000). Whole body positron emission tomography imaging of activated lymphoid tissues during acute SHIV89.6PD infection in rhesus macaques. Virology 274(2): 255-261.
8. Djavani, M, Lukashevich, IS, Sanchez, A, Nichol, ST, Salvato, MS (1997). Completion of the Lassa Fever Virus sequence and identification of a RING-finger protein gene at the 5' end of the L RNA. Virology 235: 414-418.
9. Djavani, M, Lukashevich, IS, Salvato, MS. (1998). Sequence comparison of the large genomic RNA segments of two strains of lymphocytic choriomeningitis virus differing in pathogenic potential for guinea pigs. Virus Genes 12:2, 149-153.
10. Yin, C., Djavani, M., Schenkel, A.R., Hildeman, D.A., Muller,D., Pauza,C.D., and Salvato, M.S. (1998). Dissemination of Lymphocytic Choriomeningitis Virus from the Gastric Mucosa Requires G Protein-Coupled Signaling. J. Virol. 72 (11), 8613-8619.
11. Wallace, M., Waterman, P.M., Mitchen, J.L., Djavani, M., Trivedi, P., Horejsh, D.R., Dykhuizen, M., Kitabwalla, M., Pauza, C.D. (1999). Lymphocyte activation during acute SHIV 89.6PD infection in Macaques. J. Virol. 73 (12), 10236-10244.
12. Lukashevich IS, Maryankova R, Vladyko AS, Nashkevich N, Koleda S, Djavani M, Horejsh D, Voitenok JJ and Salvato, MS (1999). Lassa and Mopeia virus replication in human monocytes/macrophages and in endothelial cells: different effects on IL-8 and TNF-? gene expression. J. Med. Virol. 59:552-560.
13. Djavani, M., Kirkali, G., Yenice, S., Guner, G., and Sessiz, H.T. (1993). Quantitation of type I and III collagen of liver in alloxan-induced diabetic rabbits. Bioch.Society,Transactions,. 21: 273S
14. Tamugur, E., Ozer, M., Guner, G., and Djavani, M. (1992). Sex difference in risk factors of lipid metabolism for coronary artery disease. J.Clinical Biochem.& Nutrition. 13: 269-278
15.

Alper, S., Ardic, F., Fuzun, S., Ekin, A., and Djavani, M. (1992). The role of synthetic Human Calcitonin in the treatment of Sudeck's atrophy. Ege Tip Dergisi, 31: 118-124.

Research Interests
Click here to view Dr. Djavani's Research Interests
University of Maryland Biotechnology InstituteUniversity of Maryland Medical System The Institute of Human Virology
725 West Lombard Street
Baltimore, Maryland 21201 USA
Office: 410-706-8614 Fax: 410-706-1952