Faculty
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Profile |
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Dr. DeVico received his PhD in 1992 from George Washington University. His graduate work in concerned the biochemical properties of reverse transcriptase, particularly the enzymes of HIV and related lenti-retroviruses. Subsequently, he worked at Advanced BioScience laboratories as a Research Scientist. His work covered many aspects of HIV virology, including the development of monoclonal antibodies, vaccine candidates and diagnostic assays. He was also involved in a collaborative effort with Dr. Gallo and members of his laboratory at LTCB, which led to the discovery of the chemokines RANTES, MIP-1a and MIP-1b as major HIV suppressor factors.
Dr. DeVico was recruited to the Institute of Human Virology in 1995 as a Tenure Track assistant professor in the basic Science Division. He became a tenured associate professor in 1998 and a member of both the Vaccine and Basic Science Divisions.
Dr. Devico continues to focus on HIV-host cell interactions, the development of HIV vaccines and the design of potential therapeutic approaches based on the activities of natural HIV suppressor factors.
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Education |
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• Ph.D. - Genetics, George Washington University, Washington, D.C., 1992.
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• B.S. - Biochemistry and Nutrition, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, 1979.
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Selected Publications |
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1. |
Machado ES, Lambert JS, Watson DC, Afonso AO, da Cunha SM, Nogueira SA, Caride E, Oliveira RH, Sill AM, DeVico A, Tanuri A. Genotypic resistance and HIV-1 subtype in Brazilian children on dual and triple combination therapy. J Clin Virol. 30:24-31. 2004 |
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2. |
Abdelwahab SF, Cocchi F, Bagley KC, Kamin-Lewis R, Gallo RC, DeVico A, Lewis GK.HIV-1-suppressive factors are secreted by CD4+ T cells during primary immune responses.PNAS 100:15006-11500 2003 |
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3. |
Finnegan, C., Berg, W., Lewis, G.K. and DeVico, A.L. Antigenic Properties of the Human Immunodeficiency Virus Transmembrane Glycoprotein During Cell-Cell Fusion. J Virol. 76: 12123-34. 2002 |
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4. |
Hone DM, DeVico AL, Fouts TR, Onyabe DY, Agwale SM, Wambebe CO, Blattner WA, Gallo RC, Lewis GK. Development of Vaccination Strategies that Elicit Broadly Neutralizing Antibodies against Human Immunodeficiency Virus Type 1 in Both the Mucosal and Systemic Immune Compartments. J Hum Virol. 5:17-23 2002 |
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5. |
Fouts, T., Godfrey, K, Bobb, K, Montefiori, D., Hanson, C., Kalyanaraman, V., DeVico, A. and Pal, R. Crosslinked HIV-1 Envelope–CD4 Receptor Complexes Elicit Broadly Cross-Reactive Neutralizing Antibodies In Rhesus Macaques PNAS 99: 11842-11847 2002 |
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6. |
Devico AL, Fouts TR, Shata MT, Kamin-Lewis R, Lewis GK, Hone DM. Development of an oral prime-boost strategy to elicit broadly neutralizing antibodies against HIV-1.Vaccine. 20:1968-74. 2002 |
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7. |
Skurnick JH, Palumbo P, DeVico A, Shacklett BL, Valentine FT, Merges M, Kamin-Lewis R, Mestecky J, Denny T, Lewis GK, Lloyd J, Praschunus R, Baker A, Nixon DF, Stranford S, Gallo R, Vermund SH, Louria DB. Correlates of nontransmission in US women at high risk of human immunodeficiency virus type 1 infection through sexual exposure. J Infect Dis.185:428-38 2002 |
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8. |
Shata MT, Reitz MS Jr, DeVico AL, Lewis GK, Hone DM. Mucosal and Systemic HIV Env-Specific CD8(+) T Cells Develop After Intragastric Vaccination with Salmonella Env DNA Vector Vaccine 20: 623-629 2001 |
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9. |
Finnegan, C., Berg, W., Lewis, G.K. and DeVico, A.L. Antigenic Properties Of The Human Immunodeficiency Virus Envelope During Cell-Cell Fusion..J. Virol. 75: 11096-11105 2001 |
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10. |
Kamin-Lewis R, Abdelwahab SF, Trang C, Baker A, DeVico AL, Gallo RC, Lewis GK. Perforin-Low Memory CD8+ Cells Are the Predominant T Cells In Normal Humans That Synthesize The Beta -Chemokine Macrophage Inflammatory Protein-1beta. Proc Natl Acad Sci U S A 98: 9283-8 2001 |
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11. |
Cocchi, F., DeVico, A.L. et al Higher MIP-1a And MIP-1b Levels From CD8+ T Cells Are Associated With Asymptomatic HIV-1 Infection. Proc Natl Acad Sci U S A. 97:13812-7 2000 |
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12. |
Fouts, T.R., Tuskan, R., Godfrey, K., Reitz, M., Lewis, G.K. and DeVico, A.L. Expression And Characterization Of A Single Chain Polypeptide Analogue Of The HIV-1 Gp120-CD4 Receptor Complex. J. Virol . 74: 11427-11436 2000 |
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13. |
RANTES Suppresses HIV-1 Infection But Does Not Activate Cognate Receptors after Binding to Glycosaminoglycans. Burns, J.M., Lewis, G.K., and DeVico, A.L. Proc Natl Acad Sci U S A. 96:14499-504 1999 |
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14. |
Garzino-Demo, A., Moss, R.B., Margolick, J., Cleghorn, F., Sill, A., Blattner, W.A., Cocchi, F., Carlo, D.J., DeVico, A.L., and Gallo, R.C. Spontaneous and antigen-induced production of HIV-inhibitory beta-chemokines are associated with AIDS-free status. Proc Natl Acad Sci U S A. 96: 11986-91 1999 |
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15. |
A New Monoclonal Antibody, mAb 4A12, Identifies a Role for the Glycosaminoglycan (GAG)1 Binding Domain of RANTES in the Anti-viral Effect Against HIV-1 and Intracellular Ca+Signaling2 . Burns, J.M., Gallo, R.C., DeVico, A.L. and Lewis, G.K., J Exp Med. 188: 1917-27 1998 |
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16. |
Pal, R., Garzino-Demo, A., Markham, P.D., Burns, J., Brown, M., Gallo, R.C., and DeVico, A.L. Inhibition of HIV-1 infection by the b chemokine, MDC. Science 287: 695-698 1997
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17. |
Garzino-Demo, A., Arya, S. K., DeVico, A. L., Cocchi, F., Lusso, P., and Gallo, R. C.: C-C Chemokine RANTES and HIV-LTR Gene Expression, AIDS Research and Human Retroviruses 13: 1367-1371 1997 |
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18. |
Secchiero, P., Sun, D., DeVico, A.L., Crowley, R.W., Reitz, M.S., Zauli, G., Lusso, P., and Gallo, R.C.: Role of the extracellular domain of human herpesvirus 7 glycoprotein B in virus binding to cell surface heparin sulfate proteoglycans. J. Virol. 71: 4571-4580 1997 |
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19. |
Cocchi, F., DeVico, A. L., Garzino-Demo, A., Cara, A., Gallo, R. C., and Lusso, P.: Inhibition of HIV-1 Entry by the C-C chemokines RANTES, MIP-1a, and MIP-1b: Critical Role of the V3 Domain of the gp120 Envelope Glycoprotein. Nature Medicine 2: 1244-1247, 1996 |
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20. |
DeVico, A.L., Silver, A., Thornton, A.M., Sarngadharan, M.G., and Pal, R.: Covalently Crosslinked complexes of human immunodeficiency virus type 1 (HIV-1) gp120 and CD4 receptor elicit a neutralizing response that includes antibodies selective for primary virus isolates. Virology 218: 258-263, 1996. |
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21. |
Thornton, A.M., Buller, R.M., DeVico, A.L., Wang, I.-M., and Azato, K. Inhibition of HIV-1 and vaccinia virus infection by a dominant negative factor of the IRF family expressed in monocytic cells. PNAS 93: 383-387, 1996. |
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22. |
Cocchi, F., DeVico, A.L., Garzino-Demo, A., Arya, S.K., Gallo, R.C., and Lusso, P.: Identification of RANTES, MIP-1a, and MIP-1ß as the major HIV-suppressive factors produced by CD8+ T cells. Science 270: 1811-1815, 1995. |
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23. |
DeVico, A.L., Rahman, R., Welch, J., Crowley, R., Lusso, P., Sarngadharan, M.G., and Pal, R.: Monoclonal antibodies raised against covalently crosslinked complexes of human immunodeficiency virus type 1 gp120 and CD4 receptor identify a novel complex-dependent epitope on gp120. Virology 211: 583-588, 1995. |
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24. |
DeVico, A. L., Rahman, R., Sarngadharan, M. G., and Veronese, F.D.: Mechanism of enzyme inhibition mediated by anti-reverse transcriptase antibodies from HIV-1-infected individuals. AIDS Res. Hum. Retroviruses 10: 953-960, 1994. |
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25. |
Pal, R., DeVico, A., Rittenhouse, S. and Sarngadharan, M. G.: Conformational perturbation of the envelope glycoprotein gp120 of human immunodeficiency virus type 1 by soluble CD4 and the lectin succinyl Con A. Virology 194: 833-837, 1993. |
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26. |
DeVico, A. L., Issel, C. J., Le Grice, S. F. J., Payne, S. L., Montelaro, R. C. and Sarngadharan, M. G.: High prevalence of serum antibodies to equine infectious anemia virus reverse transcriptase. AIDS Res. Hum. Retroviruses 9: 7-11, 1993. |
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27. |
Nair, B. C., DeVico, A. L., Nakamura, S., Copeland, T. D., Chen, Y., Patel, A., O'Neil, T., Oroszlan, S., Gallo, R. C. and Sarngadharan, M. G.: Identification of a major growth factor for AIDS - Kaposi's sarcoma cells as Oncostatin M. Science 255: 1430-1432, 1992. |
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28. |
Lori, F., Veronese, F.D., DeVico, A.L., Lusso, P., Reitz, M.S. and Gallo, R.C.: Viral DNA carried by human immunodeficiency virus type 1 virions. J. Virol. 66: 5067-5074, 1992. |
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29. |
DeVico, A. L., Copeland, T. D., Oroszlan, S., Gallo, R. C. and Sarngadharan, M. G.: Interaction of C-terminal sequences of human immunodeficiency virus reverse transcriptase with template primer. J. Biol. Chem. 266: 6774-6779, 1991. |
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30. |
Stein, C. A., Pal, R., DeVico, A. L., Hoke, G., Mumbauer, S., Kinstler, O., Sarngadharan, M. G. and Letsinger, R. L.: Mode of action of 5' linked-cholesteryl phosphorothioate oligodeoxynucleotides in inhibiting syncytia formation and infection by HIV-1 and HIV-2 in vitro. Biochem. 30: 2439-2444, 1991. |
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31. |
DeVico, A. L., Montelaro, R. M., Copeland, T. D., Oroszlan, S. and Sarngadharan, M. G.: Purification and partial characterization of equine infectious anemia virus reverse transcriptase. Virology 185: 387-394, 1991. |
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32. |
Kalyanaraman, V. S., Rodriguez, V., Veronese, F., Rahman, R., Lusso, P., DeVico, A. L., Copeland, T., Oroszlan, S., Gallo, R. C. and Sarngadharan, M. G.: Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1. AIDS Res. Hum. Retroviruses 6: 371-379, 1990. |
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33. |
DeVico, A. L., Copeland, T. D., Veronese, F. D., Oroszlan, S., Gallo, R. C. and Sarngadharan, M. G.: Purification and partial characterization of human immunodeficiency virus type 2 reverse transcriptase. AIDS Res. Hum. Retroviruses 5: 51-60, 1989. |
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34. |
Hao, Z., Cooney, D. A., Hartman, N. R., Perno, C. F., Fridland, A., DeVico, A. L., Sarngadharan, M. G., Broder, S. and Johns, D. G.: Factors determining the activity of 2',3'-dideoxynucleosides in suppressing human immunodeficiency virus in vitro. Mol. Parmacol. 34: 431-435, 1988. |
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35. |
DeVico, A. L., Veronese, F. D., Lee, S. L., Gallo, R. C. and Sarngadharan, M. G.: High prevalence of serum antibodies to reverse transcriptase in HIV-1-infected individuals. AIDS Res. Hum. Retroviruses 4: 17-22, 1988. |
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36. |
Mitsuya, H., Jarrett, R. F., Matsukura, M., Veronese, F. D., DeVico, A. L., Sarngadharan, M. G., Johns, D. G., Reitz, M. S. and Broder, S.: Long-term inhibition of human T-lymphotropic virus type III/lymphadenopathy-associated virus (human immunodeficiency virus) DNA synthesis and RNA expression in T cells protected by 2', 3'- dideoxynucleosides in vitro. Proc. Natl. Acad. Sci. USA 84: 2033-2037, 1987. |
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37. |
Veronese, F. D., Copeland, T. D., DeVico, A. L., Rahman, R., Oroszlan, S., Gallo, R. C., and Sarngadharan, M. G.: Characterization of the highly immunogenic p66/p51 as the reverse transcriptase of HTLV-III/LAV. Science 231: 1289-1291, 1986. |
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38. |
Veronese, F. D., DeVico, A. L., Copeland, T. D., Oroszlan, S., Gallo, R. C. and Sarngadharan, M. G.: Characterization of gp41 as the transmembrane protein coded by the HTLV-III envelope gene. Science 229: 1402-1405, 1985. |
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39. |
Sarngadharan, M.G., DeVico, A.L., Brüch, L., Schüpbach, J. and Gallo, R. C.: HTLV-III: The etiologic agent for AIDS. In: Retroviruses in Human Lymphoma/Leukemia, Miwa, M., Sugano, H., Sugimura, T., and Weiss, R. (eds.), Japan Scientific Societies Press, Tokyo, pp. 301-308, 1985. |
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40. |
Groopman, J. E., Mayer, K. H., Sarngadharan, M. G., Ayotte, D., DeVico, A. L., Finberg, R., Sliski, A. H., Allan, J. D. and Gallo, R. C.: Seroepidemiology of HTLV-III among homosexual men with acquired immunodeficiency syndrome or generalized lymphadenopathy and among asymptomatic controls in Boston. Ann. Int. Med. 102: 334-337, 1985. |
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41. |
Sarngadharan, M. G., Schüpbach, J., Brüch, L., DeVico, A. L., Markham, P. D.,
Wong-Staal, F. and Gallo, R. C.: Seroepidemiological evidence for HTLV-III infection in the etiology of acquired immunodeficiency syndrome. In: Infection, Immunity, and Blood Transfusion, Dodd, R., and Baker, L. F. (eds.), Alan R. Liss, New York, pp. 309-327, 1985. |
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42. |
Jaffe, H. W., Sarngadharan, M. G., DeVico, A. L., Brüch, L., Getchell, J. P., Kalyanaraman, V. S., Kilbourne, B. W., Haverkos, H. W., Nicholson, J. K. A., Stoneburner, R. L., Gallo, R. C., Francis, D. P. and Curran, J. W.: Serologic evidence of an etiologic role for a human T-lymphotropic retrovirus (HTLV-III/LAV) in transfusion-associated AIDS. J. Am. Med. Assoc. 253: 770-773, 1985.
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Research Interests |
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Click here to view Dr. DeVico's Research Interests |
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