Faculty
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Division of Epidemiology and Prevention
Niel T. Constantine, Ph.D.
Professor, University of Maryland School of Medicine
nconstantine@ihv.umaryland.edu
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| Profile |
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Dr. Niel T. Constantine, a professor in the Department of Pathology, possesses 29 years of experience in the diagnostic arena, acts frequently as an international consultant for laboratory strengthening activities in many countries, and has a productive track record with extramural funding and publications.
After obtaining a degree in Medical Technology, he completed his Ph.D. in Pathology at the University of Maryland School of Medicine, and subsequently was appointed Director of the Clinical Immunology Laboratory at the Medical Center Hospital. Among his international contributions, he spent three years at the U.S. Naval Medical Research Unit #3 in Cairo Egypt where he established and headed a laboratory for HIV surveillance that became a WHO Collaborating Centre for HIV in the Eastern Mediterranean Region, and in 1993, Dr. Constantine was recruited to Geneva to work with the WHO Global AIDS Programme in the Diagnostics Unit for establishing research protocols in a number of countries, and addressing issues in global diagnostics for HIV. In 1996, Dr. Constantine established the Laboratory of Viral Diagnostics, a strong research unit at the Institute of Human Virology that provides support for several divisions and conducts developmental test research.
Dr. Constantine's efforts have resulted in the publication of more than 130 articles, including 3 books, 12 book chapters, and nearly 200 abstracts, most of which describe new technologies and their applications. Of particular note is his book on Retroviral Testing and Quality Control which is used in laboratories throughout the world
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Dr. Constantine has had numerous grant awards, including numerous commercially-sponsored grants for clinical trials, two from the Department of Defense, others from the World AIDS Foundation and the Doris Duke Foundation, and currently entertains 2 NIH funded grants and 1 from the CDC for test development.
Dr. Constantine’s major consultant activities include those from the World Bank, USAID, and the WHO for laboratory strengthening in the countries of Egypt, Thailand, Uganda, India, Indonesia, and the Philippines, and he is currently active in a multi-million dollar PEPFAR grant from the CDC for laboratory strengthening activities for HIV in Nigeria.
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| Education |
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Ph.D. - Pathology, University of Maryland, Baltimore, 1981. |
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B.S. - Medical Technology, University of Maryland, Baltimore, 1974. |
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B.A. - Psychology, University of Maryland, Baltimore, 1973. |
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| Selected Publications |
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Barletta, J.M., Edelman, D.C., & Constantine,
N.T. Lowering the detection limits of HIV-1 viral load using real-time
immuno-PCR for HIV-1 p24 antigen. American Journal of Clinical
Pathology, 122: 20-27, 2004. |
Constantine, N.T., Saville, R., & Dax, E. Retroviral Testing and Quality
Assurance: Essential for
Laboratory Diagnosis. Ann Arbor, MI: Malloy Printers, ISBN 0-9785982-0-2, 701
p, 2005 |
Constantine, N.T. & Zink, H. HIV testing technologies after 2 decades of
evolution. Indian Journal of Medical Research, 121:519-538, 2005. |
Ketema, F., Zink, H., Croxton, T., Kreisel, K.,
& Constantine, N.T. A 10-minute USFDA approved HIV test. Expert Review
of Molecular Diagnostics, 5:135-143, 2005. |
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Constantine, N.T. & Zhao, R.Y. Molecular-based laboratory testing and monitoring
for human immunodeficiency virus infections. Clinical Laboratory Science,
18(4):263-70, 2005. |
Constantine, N.T., Kabat, W., & Zhao, R.Y. Update on the laboratory diagnosis and
monitoring of HIV infection. Cell Research, Nov-Dec; 15(11-12):870-6, 2005. |
Sill, A.M., Kreisel, K., Deeds, B.G., Wilson, C.M., Constantine,
N.T., Peralta, L., & the Adolescent Trials Network (ATN) for HIV/AIDS
Intervention. Calibration and validation of an oral fluid-based S/LS assay to
distinguish recent from established HIV-1 infection. Journal of Clinical
Laboratory Analysis, 21:40-45, 2007. |
Sajadi, M., Heredia, A., Le, N., Chan-Tack, K., Constantine,
N., DeVico, A., & Redfield, R. HIV-1 natural viral suppressors: Control of viral replication in the
absence of therapy. AIDS, Feb; 21:517-528, 2007 |
Hong, L., Ketema, F., Sill, A., Kreisel, K.,
Cleghorn, F.R., & Constantine, N.T. A simple and inexpensive particle
agglutination test to distinguish recent and established HIV-1 infection.
International Journal of Infectious Disease, 11:459-465, 2007 |
Highsmith, W.E., Constantine, N.T., &
Friedman, K.F. Molecular diagnostics, (Chapter 48). In: L. Kaplan, A.
Pesche, & Kazmierszak (Eds), Clinical Chemistry, 5th Ed. NY:
Mosby, In press, 2008. |
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| Research Interests |
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| Click here to view Dr. Constantine's Research Interests |
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