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Open Clinical Trials

Clinical trials are studies designed to find new and better ways to treat patients. Through clinical trials, scientists and physicians at the Institute of Human Virology have broken new ground in the development of treatments. To enroll in a study call 410-706-1684.

The following clinical trials are currently open and accepting participants. Click a trial name below to learn more about the trial, including how to get involved. The eligible population is in parenthesis ( ) next to the trial name.

The HOPE Study (Healthy Volunteers, Hepatitis C, Hepatitis B)

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HOPE: An Omnibus Protocol to Characterize Patients with Hepatitis B and C is a research trial for adults who have or have had viral hepatitis B and/or hepatitis C and sometimes healthy volunteers (for comparison) and adults with chronic hepatitis B.

What it Does

  • Collects blood samples 1-2 times each year for up to 10 years to study the viruses and the immune system.
  • Provides Tenofovir Alafenamide (TAF) for two years with visits every three months to collect blood samples.

What it's For

  • Provides Tenofovir Alafenamide (TAF) for two years with visits every three months to collect blood samples.
  • Adults 18 and over
  • With hepatitis B or C, or who have cleared hepatitis B or C, or healthy volunteers

To Be Eligible You Must:

  • Be 18 years old and over
  • Have hepatitis B or C, or who have cleared hepatitis B or C, or be a healthy volunteer
  • Have blood samples stored for future research
  • Must have a primary care provider
  • Be willing to have HIV testing
  • Have veins that allow specimen collection
  • May not be pregnant or breastfeeding

For More Information

  • For information about the annual visit blood draw study, contact: Haley Ward, 410-706-6569
  • For information about the sub-study with standard-of-care treatment for chronic hepatitis B contact: Ka Wing (Joyce) Lam, 410-706-3367
  • Or go to www.clinicaltrials.gov

MAVERIC (Hepatitis C)

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MAVERIC is a research study to test whether the HIV medication called maraviroc affects the hepatitis C virus. All study visits will be conducted at the Institute of Human Virology at the University of Maryland. All study medicine and testing are provided free to participants. Compensation for travel and time is provided.

To Be Eligible You Must Be:

  • 18 years or older
  • Have untreated hepatitis C
  • Have HIV and are on treatment

For More Information Contact:

Dr Lydia Tang at 410-706-6567 or go to www.clinicaltrials.gov.

MISP (Hepatitis C and Pre and Post Kidney Transplant)

MISP is a study evaluating the use of FDA approved medication Zepatier (Grazoprevir and Elbasvir) to see if there is difference in the immune system response to treatment either before or after kidney transplant. Medication will be provided free of cost and research blood samples will be collected.

To Be Eligible You Must:

  • Be 18 years or older
  • Have hepatitis C (genotype 1) infection
  • Not have liver cirrhosis
  • Have either chronic kidney disease or have had a kidney transplant

For More Information Contact:

RESOLVE (Hepatitis C)

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RESOLVE is an investigational hepatitis C retreatment study for people with hepatitis C who have previously failed treatment with combination directly-acting antiviral agents, including Harvoni, Viekira Pak, and Zepatier. The study aims to assess the safety, tolerability, and efficacy of 12 weeks of an investigational all oral combination DAA therapy composed of sofoxbuvir/velpatasvir/voxilaprevir in subjects with chronic HCV infection who have previously failed DAA-based therapy, either with compensated cirrhosis or without cirrhosis.

To Be Eligible You Must:

  • Be willing to attend 10 study visits over the course of 36 weeks
  • Be HIV positive or negative
  • Be over 18
  • Have no history of transplantation, significant cardiac or psychiatric disease
  • Have normal laboratory results, and must be willing to provide informed consent.
  • Women may not be pregnant and must be willing to use contraception.

Compensation is provided for travel.

For More Information Contact:

Jennifer Hoffmann, RN, CRNP, MPH at 410-706-0294 or
Emily Comstock, RN, CRNP at 410-706-4322 or
Visit www.clinicaltrials.gov.

RT5 (Hepatitis C and Post Kidney Transplant)

RT5 is a study to evaluate the use of FDA approved medications (Maraviroc and Sirolimus) in HIV+ kidney transplant recipients to determine if it will reduce HIV DNA. Medications will be paid for through the volunteers insurance, research blood samples will be collected.

To Be Eligible You Must:

  • Be HIV+
  • Be at least 6 months post-kidney transplant with stable kidney function
  • On antiretroviral therapy for at least 6 months
  • Have a CD4 count >200

For More Information Contact:

Ilise Marrazzo, RN, MPH at 410-706-2564 or visit www.clinicaltrials.gov.


IHV Clinical Trials Unit

Institute of Human Virology
725 W. Lombard Street
Baltimore, MD 21201

Directions to IHV Patient Parking

To enroll in a study call 410-706-1684.